Pokemon Puzzle Challenge (Pokemon de Panepon in Japan) is a spin-off puzzle game that was created for the Game Boy Color. The games was published by Nintendo and developed by Intelligent Systems.

Pokemon Puzzle Challenge was released for the Game Boy Color on September 21st, 2000 in Japan and December 4th, 2000 in North America to act as a handheld supplement to the N64 puzzle spin off title, Pokemon Puzzle League. Players battle through several different game modes, battling the various Johto gym leaders in puzzle games, unlocking and hatching Pokemon eggs, and playing against your friends via multiplayer matches. The game also includes a "Puzzle" mode in which players attempt to use combos to clear all the blocks onscreen within a certain number of moves.